Selective Neuronal Vulnerability in Neurodegeneration [Video]

Presented By: Marija Cvetanovic, PhD

Speaker Biography: Dr. Marija Cvetanovic is Associate Professor at the Department of Neuroscience and a Scholar at the Institute for Translational Neuroscience at the University of Minnesota, Minneapolis. Dr. Cvetanovic received an education in Molecular Biology and Physiology (University of Belgrade, Serbia), Immunology, Microbiology and Virology (PhD, University of Illinois in Chicago, USA), and Neuroscience (Postdoctoral fellow, Northwestern University, USA). Cvetanovic laboratory employs mouse and viral genetics, cell and molecular biology techniques, mouse behavior, fiber photometry, transcriptomics, and disease modeling with induced pluripotent stem cells, to investigate the cellular and molecular pathways that underlie the pathology of neurodegenerative disorders.

Webinar: Selective Neuronal Vulnerability in Neurodegeneration

Webinar Abstract: Selective vulnerability of brain regions and specific neural populations in neurodegeneration remains little understood. We hypothesize that pre-existing physiological differences in neurons and in surrounding glia across brain regions are likely to contribute to their selective vulnerability in disease. Spinocerebellar Ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by an abnormal expansion of polyglutamine (polyQ) repeats in the ATXN1 protein and characterized by early and severe cerebellar degeneration. Using histological approaches, we first demonstrated that the cerebellum of SCA1 mice does not undergo degeneration uniformly with worse Purkinje cell atrophy and gliosis in the posterior vermis, as seen in patients with SCA1….

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