OHBM 2023 | 3024 | Talk | Barbara Hollunder | Mapping Dysfunctional Circuits in the Frontal Cortex… [Video]

Title: Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.
Session: Oral Session
Speaker: Barbara Hollunder
Abstract: Neurocircuits are involved in motor, cognitive, and affective brain (dys)function (Bonelli & Cummings, 2007; Haber et al., 2021). Functional segregation into these domains has been widely defined on a cortical basis (Haber et al., 2021). However, despite considerable interaction, these functional domains remain partitioned to some extent at the subcortical level (Haynes & Haber, 2013). In humans, neuroimaging studies have been the main method to segregate the frontal cortex into functionally specific zones. Here we leverage a different approach based on optimal connectivity profiles from therapeutic deep brain stimulation (DBS) electrodes to the same surgical target, receiving input from the entire frontal cortex (Benarroch, 2008), in four different disorders. Namely, we identify cortical projection sites that, on a group level, associate with maximal improvements following DBS to the subthalamic nucleus (STN) in dystonia (DYT), Parkinson’s disease (PD), Tourette syndrome (TS) and obsessive-compulsive disorder (OCD).