Maternal Inheritance Linked to Higher Alzheimer’s Disease Risk, JAMA Study finds [Video]

#mitochondriadna #alzheimers #braindisorder

A new study by researchers from Mass General Brigham, published in JAMA Neurology, suggested that whether a person inherits risk of Alzheimer’s disease from their mother or father influences risk of biological changes in the brain that lead to disease.
Alzheimer’s disease is a progressive neurodegenerative disorder that primarily affects memory and cognitive function. It is characterised by the buildup of amyloid plaques and tau tangles in the brain.
Research has indicated that individuals with a maternal history of Alzheimer’s disease have an increased risk of developing the condition. This heightened risk is believed to be linked to genetic factors and mitochondrial DNA inherited from the mother. Mitochondria, which are crucial for cellular energy production, are exclusively inherited from the mother, and any mitochondrial dysfunction can contribute to the development and progression of Alzheimer’s disease.

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