Managing & Treating Alzheimer’s Disease | New Treatment & Drugs For Alzheimer’s | [Video]

Alzheimer’s has no cure, but certain medicines can help manage symptoms of the disease and some can slow down disease progression.

Alzheimer’s drugs don’t work for everyone and may lose effectiveness over time. These medicines tend to be most effective for people with early to moderate Alzheimer’s disease.

To date, only symptomatic therapies for Alzheimer disease (AD) are available and thus do not act on the evolution of the disease

The standard medical treatment for AD includes….

1. cholinesterase inhibitors (ChEIs)….

It prevent the breakdown of acetylcholine.

Three such agents have been approved by the FDA ;:

Donepezil (Aricept, Aricept ODT)

Rivastigmine (Exelon, Exelon Patch)

Galantamine (Razadyne, Razadyne ER)

2. partial N -methyl-D-aspartate (NMDA) antagonist

3. Additionally, amyloid-directed antibodies ……..(eg, aducanumab, lecanemab)….. have been approved.

Various mentioned Secondary symptoms of AD (eg, depression, agitation, aggression, hallucinations, delusions, sleep disorders) can be problematic. …….

The following classes of psychotropic medications have been used …… These include

Antidepressants

Anxiolytics

Antiparkinsonian agents

Beta-blockers

Antiepileptic drugs

Neuroleptics

Now Targets of various drugs against Alzheimer’s…. Include…

beta-amyloid production, aggregation, and clearance,….

as well as tau phosphorylation and assembly.