In this video, Melissa E Murray, PhD, Mayo Clinic, Jacksonville, FL, provides insights into the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS). This is a longitudinal, observational study enrolling cognitively impaired and normal individuals aged 40-65 to study the development of early-onset Alzheimer’s disease (AD). The study assesses clinical, imaging, biomarker, and genetic characteristics. While autosomal dominant cases with PSEN1/2 and APP mutations are relatively well studied, much remains unknown about sporadic early-onset AD. LEADS will bring together numerous sites internationally to track biomarkers in these individuals, gain a better understanding of the genetic and biological processes involved in sporadic cases, and to bring more awareness to early onset AD. This interview took place at the AP/PD™ 2024 congress in Lisbon, Portugal.
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